Mucus

Persons with Infection Table 1. Table 1. Demographic and Clinical Characteristics of the Persons with Monkeypox. A total of 528 cases of confirmed human monkeypox infection from five continents, 16 countries, and 43 clinical sites are included in this series ( Figure 1 ). Demographic and clinical characteristics of the persons with infection are summarized in Table 1 . Table 2. Table 2. Demographic and Clinical Characteristics of Persons with HIV Infection in the Case Series. Overall, 98% of the persons with infection were gay or bisexual men, and 75% were White. The median age was 38 years. A total of 41% of the persons were living with HIV infection, and in the vast majority of these persons, HIV infection was well controlled; 96% of those with HIV infection were taking ART, and in 95% the HIV viral load was less than 50 copies per milliliter ( Table 2 ). Preexposure prophylaxis had been used in the month before presentation in 57% of the persons who were not known to have HIV

Abstract Invasive fungal pathogens are major causes of human mortality and morbidity 1,2 . Although numerous secreted effector proteins that reprogram innate immunity to promote virulence have been identified in pathogenic bacteria, so far, there are no examples of analogous secreted effector proteins produced by human fungal pathogens. Cryptococcus neoformans , the most common cause of fungal meningitis and a major pathogen in AIDS, induces a pathogenic type 2 response characterized by pulmonary eosinophilia and alternatively activated macrophages 3,4,5,6,7,8 . Here, we identify CPL1 as an effector protein secreted by C. neoformans that drives alternative activation (also known as M2 polarization) of macrophages to enable pulmonary infection in mice. We observed that CPL1-enhanced macrophage polarization requires Toll-like receptor 4, which is best known as a receptor for bacterial endotoxin but is also a poorly understood mediator of allergen-induced type 2 responses 9,10,11,12 . We

Juneau, Alaska (KINY) - The Sitka Police Department is warning Sitkans about school kids taking part in a social media trend known as the "Triple C challenge." The trend originated on TikTok, a social app used to create and share videos. The challenge prompts teens to take dangerously high amounts of Coricidin Cough & Cold medicine to get a "high" feeling. Serena Wild, Assistant to Sitka's Police Chief, said they had received a report from a local grocery store saying they were concerned about how much the middle schoolers seemed to be purchasing the cough medicine. Wild said they reviewed the footage and noticed the medicine was disappearing off the shelves, and that it seemed like middle schoolers were in the area of the shelves when the items were going missing. Coricidin Cough & Cold medicine is an addictive over-

Introduction Gastrointestinal parasitic infections are one of the global health concerns in developing countries like Bangladesh. Among them, Cryptosporidium spp. plays an essential role in causing diarrhea, malnutrition, and poor cognitive function, especially in children. This study was conducted to identify the frequency of Cryptosporidium cases and other parasitic agents.  Methods A cross-sectional observational study was conducted among 219 hospitalized children with diarrhea. The conventional microscopic technique was applied for parasitic detection. Particular staining (modified Ziehl-Neelsen) procedure was performed to identify oocysts of Cryptosporidium spp . A polymerase chain reaction (PCR) was performed to determine the SSU rRNA and gp60 gene of Cryptosporidium.  Results Cysts of Giardia duodenalis (2.3%), ova of Ascaris lumbricoides (1.4%,), Trichuris trichiura (0.5%), and both A. lumbricoides and T. trichiura (0.9%) we