Mucus

To study how parasites evolve to break the defenses of their hosts, the National Institutes of Health has granted UC Riverside nematologist Simon "Niels" Groen a $1.9 million Outstanding Investigator Award.  UC Riverside nematologist Simon "Niels" Groen. (Stan Lim/UCR) Roundworm parasites infect humans, livestock, and crop plants. Insights into why certain worms can evade host immune protections could help preempt a ticking time bomb: the decreasing effectiveness of pesticides and antibiotics for infections.   Bacterial, fungal, and parasite resistance to drugs and pesticides is making it harder, and sometimes impossible, to treat common infections like pneumonia and tuberculosis in humans and pest infestations in crops. International health officials warn that without urgent action, we are heading toward a future in which minor injuries and infections can kill. Crop and livestock production will also face increasing ...

Science Bird flu could jump to humans any day. A former surgeon general says it feels like 2020 again. Morgan McFall-Johnsen ...

Abstract In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biologically characterize features of A/bat/Egypt/381OP/2017(H9N2). The virus has a pH inactivation profile and neuraminidase activity similar to those of human-adapted IAVs. Despite the virus having an avian virus–like preference for α2,3 sialic acid receptors, it is unable to replicate in male mallard ducks; however, it readily infects ex-vivo human respiratory cell cultures and replicates in the lungs of female mice. A/bat/Egypt/381OP/2017 replicates in the upper respiratory tract of experimentally-infected male ferrets featuring direct-contact and airborne transmission. These data suggest that the bat A(H9N2) virus has features associated with increased risk to humans without a shift ...

Abstract The present study aimed to explore the underlying mechanism of bile reflux-inducing chronic atrophic gastritis (CAG) with colonic mucosal lesion. The rat model of CAG with colonic mucosal lesion was induced by free-drinking 20 mmol/L sodium deoxycholate to simulate bile reflux and 2% cold sodium salicylate for 12 weeks. In comparison to the control group, the model rats had increased abundances of Bacteroidetes and Firmicutes but had decreased abundances of Proteobacteria and Fusobacterium . Several gut bacteria with bile acids transformation ability were enriched in the model group, such as Blautia , Phascolarctobacter , and Enterococcus . The cytotoxic deoxycholic acid and lithocholic acid were significantly increased in the model group. Transcriptome analysis of colonic tissues presented that the down-regulated genes enriched in T cell receptor signaling pathway, antigen processing and presentation, Th17 cell differentiation, Th1 and Th2 cell differenti...